Publications
The Research Training Group (RTG) “Bioactive Peptides – Innovative Aspects of Synthesis and Biosynthesis” was established in 2019. Publications based on the RTG projects are listed below. Publications of the participating research departments are listed on their respective websites.
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21. Zborovsky L & Kleebauer L, Seidel M, Kostenk A, von Eckardstein L, Gombert FO, Weston JD, Süssmuth RD (2021) Improvement of the antimicrobial potency, pharmacokinetic and pharmacodynamic properties of albicidin by incorporation of nitrogen atoms. Chemical Science, doi: 10.1039/d1sc04019g
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20. Grass LM, Wollenhaupt J, Barthel T, Parfentev I, Urlaub H, Loll B, Klauck E, Antelmann H, Wahl MC (2021) Large-scale ratcheting in a bacterial DEAH/RHA-type RNS helicase that modulates antibiotics susceptibility Proc Natl Aced Sci USA Vol. 118, No. 30, e2100370118, https://doi.org/10.1073/pnas.2100370118
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19. Yao G, Knittel CH, Kosol S, Wenz MT, Keller BG, Gruß H, Braun AC, Lutz C, Hechler T, Pahl A, Süssmuth RD (2021) Iodine-Mediated Tryptathionine Formation Facilitates the Synthesis of Amanitins. J. Am. Chem. Soc. 2021, https://doi.org/10.1021/jacs.1c06565
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18. Kleebauer L, Zborovsky L, Hommernick K, Seidel M, Weston J, Süssmuth RD (2021) Overcoming AlbD protease resistance and improving potency: Synthesis and bioactivity of antibacterial albicidin analogues with amide bond isosteres. Org. Lett. 2021. https://doi.org/10.1021/acs.orglett.1c02312
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17. Schneider AFL, Benz L, Lehmann M, Hackenberger CPR (2021) Cell-Permeable Nanobodies Allow Dual-Color Super-Resolution Microscopy in Untransfected Living Cells. Angew. Chem. Int. Ed. 2021, 60, 2-8, DOI: 10.1002/anie.202103068
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16. Lenz S, Sinn L, O´Reilly FJ, Fischer L, Wegner F, Rappsilber J (2021) Reliable identification of protein-protein interactions by crosslinking mass spectrometry. Nat. Comm. 12:3564, doi:10.1038/s41467-021-23666
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15. Stieger CE, Franz L, Körlin F, Hackenberger CPR (2021) Diethynyl Phosphinates for Cysteine-Selective Protein Labeling and Disulfide Rebridging. Angew. Chem. Int. Ed. 60, 1-7. doi:0.1002/anie.202100683
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14. Giese SH, Sinn L, Wegner F, Rappsilber J (2021) Retention time prediction using neural networks increases identifications in crosslinking mass spectrometry. Nat. Comm. 12: 3237, doi:10.1038/s41467-021-23441-0
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13. Wiebach V, Mainz A, Schnegotzki R, Siegert MAJ, Hügelland M, Pliszka N, Süssmuth RD (2020) An Amphipathic Alpha-Helix Guides Maturation of the Ribosomally-Synthesized Lipolanthines. Angew Chem (59), 16777-16785, doi.org/10.1002/anie.202003804
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12. Schneider AFL, Kithil M, Cardoso MC, Lehmann M, Hackenberger CPR (2021) Cellular uptake of large biomolecules enabled by cell-surface-reactive cell-penetrating peptide additives.
Nature Chemistry, doi: 10.1038/s41557-021-00661-x
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11. Behroz I, Kleebauer L, Hommernick K, Seidel M, Grätz S, Mainz A, Weston JB, Süssmuth RD (2021) Acetylenic Replacement of Albicidin’s Methacrylamide Residue Circumvents Detrimental (E)‐(Z)‐Photoisomerization and Preserves Antibacterial Activity. Chemistry, doi: 10.1002/chem.202100523
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10. Said N, Hilal T, Sunday ND, Kathri A, Bürger J, Mielke T, Belugorov BA, Loll B, Sen R, Artsimovitch I, Wahl MC (2021) Steps toward translocation-independent RNApolymerase inactivation by terminator ATPaser. Science 371 (6524), doi: 10.1126/science.abd1673
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9. Roske JJ, Lui S, Loll B, Neu U, Wahl MC (2021) A skipping rope translocation mechanism in awidespread family of DNA repair helicases. Nucleic Acid Research 49 (1), doi: 10.1093/nar/gkaa1174
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8. Pei HH, Hilal T, Chen ZA, Huang YH, Gao Y, Said N, Loll B, Rappsilber J, Belogurov GA, Artsimovitch I, Wahl MC (2020) The δ subunit and NTPase HelD institute a two-pronged mechanism for RNA polymerase recycling. Nat Commun. 11(1):6418. doi: 10.1038/s41467-020-20159-3.
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7. Siegert MJ, Knittel CH, Süssmuth RD (2020) A Convergent Total Synthesis of Death Cap Toxin α-Amanitin. Angew Chem Int Ed Engl. 59(14), 5500-5504. doi: 10.1002/anie.201914620.
Corresponding cover picture: doi: 10.1002/anie.202001279
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6. Wahl MC, Sen R (2019) Exploiting phage strategies to modulate bacterial transcription. Transcription 10, 222-230. doi: 10.1080/21541264.2019.1684137
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5. Apel C, Kasper MA, Stieger CE, Hackenberger CPR, Christmann M (2019) Protein Modification of Lysine with 2-(2-Styrylcyclopropyl)ethanol. Org. Lett. 21, 10043–10047. doi: 10.1021/acs.orglett.9b03982
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4. Cairns T, Feurstein C, Zheng X, Zheng P, Sun J, Meyer V (2019) Functional exploration of co-expression networks identifies a nexus for modulating protein and citric acid titres in Aspergillus niger submerged culture. Fungal Biol Biotechnol. 6, 18. doi: 10.1186/s40694-019-0081-x
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3. Cairns T, Feurstein C, Zheng X, Zheng P, Sun J, Meyer V (2019) A quantitative image analysis pipeline for the characterization of filamentous fungal morphologies as a tool to uncover targets for morphology engineering: a case study using apID in Aspergillus niger. Biotechnol Biofuels. 12, 1-17. doi: 10.1186/s13068-019-1473-0
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2. Dehm D, Krumbholz J, Baunach M, Wiebach V, Hinrichs K, Guljamow A, Tabuchi T, Jenke-Kodama H, Süssmuth RD, Dittmann E (2019) Unlocking the Spatial Control of Secondary Metabolism Uncovers Hidden Natural Product Diversity in Nostoc punctiforme. ACS Chem. Biol. 14, 1271–1279. doi: 10.1021/acschembio.9b00240
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1. Guiyang Y, Joswig JO, Keller BG, Süßmuth RD (2019) Total Synthesis of the Death Cap Toxin Phalloidin: Atropoisomer Selectivity Explained by Molecular‐Dynamics Simulations. Chem. Eur. J. 25, 8030-8034. doi:10.1002/chem.201901888
